ANYL 47 |
| Calcium phosphate matrix (CPM) is a bone cement that is used as a delivery matrix for rhBMP-2 protein. In an injectable paste formulation, rhBMP-2/CPM is used in the therapeutic treatment of closed metaphyseal and diaphyseal long bone fractures. CPM is a dry powder composed of NABSM (a calcium phosphate cement) and sodium bicarbonate. Specific surface area (SSA), as measured via the gas adsorption method utilizing BET calculations, is an important property of CPM as a means of characterizing the rhBMP-2/CPM product. SSA is used to characterize the NABSM bulk powder component of CPM. It is also used to evaluate the kinetic properties of rhBMP-2/CPM paste as it undergoes conversion to a hardened cement. Lastly, SSA measurements of the fully converted cement can be linked to particle size and porosity. All such SSA measurements on CPM have lead to a better understanding of the performance of the rhBMP-2/CPM product. |
|
General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |