ANYL 313 |
| Viscosity of LC solvent systems limits the speed at which one can conduct the analysis. This, in turn, retards the throughput of a single system. The lower viscosity of supercritical fluids, such as carbon dioxide, enables faster flow rates. Also higher diffusivity yields greater efficiency (smaller plate heights) reducing column length required to resolve a sample. Shorter column lengths and an increase in flow rate greatly reduces chromatographic time, thus SFC is amenable to increasing the throughput of analysis. As the synthetic route to create Active Pharmaceutical Ingredients (APIs) increases in complexity, the analysis of the reaction mixture becomes more difficult. Hyphenated techniques enable the analyst to identify the chemical entities in a matrix and determine relative abundance of desired product or impurity when combined light absorption data. The objective of this presentation is to demonstrate how adopting the hyphenated technique of SFC-MS can minimize the looming bottle-neck of analysis through increased efficiency due to the technique coupled with the seamless integration into known software. |
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Analytical Approaches: Separation Science
8:30 AM-12:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 130, Oral
Division of Analytical Chemistry |