Synthesis of B-cyclodextrin derivatized erythromycin used as chiral selector in capillary electrophoresis

ANYL 145

Rongji Dai, dairongji@bit.edu.cn1, Xiaoying Nie, N/A1, Bin Tong2, Weiwei Meng, N/A1, and Yulin Deng, deng@bit.edu.cn1. (1) School of Life Science and Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, China, (2) School of Metarials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
A water-soluble new â-CD derivatized erythromycin was synthesized and used as an effective chiral selector for the capillary zone electrophoretic resolution of six chiral compounds. Substitution with 1-oxygen-2,3-epoxypropane erythromycin oxime at the primary hydroxyl site of the â-CD is aimed at producing cooperative functioning of the â-CD and the erythromycin. â-CD derivatized erythromycin exhibited excellent enantioselectivities comparing that with single â-CD and erythromycin for chiral separation in CE. We also investigated the influence of pH and concentration of the BGE, the concentration of the chiral selector, the applied potential and the organic modifier on chiral compounds separation.
 

General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Analytical Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006