ANYL 98 |
| Vibrational circular dichroism (VCD) has become a powerful tool for the absolute stereochemistry determination of chiral molecules. The sensitivity of VCD to the (three-dimensional) conformations of chiral molecules potentially makes it an ideal tool to be used in conjunction with commercially available multivariate data analysis software to understand structure-activity (SAR) or structure-property (SPR) relationships of potential drug leads. In the current study, VCD spectra of selected chiral molecules ranging from non-biologically active to biologically active were measured and multivariate data analysis carried out. The correlations between the VCD features and drug properties will be presented. |
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General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |