TOXI 63 |
| Acrylamide is a neurotoxic, mutagenic, and carcinogenic industrial chemical and food contaminant. We have assessed the relationships between serum levels of acrylamide and its genotoxic metabolite glycidamide and the levels of hemoglobin and DNA adducts in mice and rats administered single or repeated doses of acrylamide or glycidamide. There were significant linear relationships between the area under the serum time-concentration curve (AUC) for glycidamide and both liver glycidamide DNA adducts and glycidamide hemoglobin adducts in rodents administered either acrylamide or glycidamide (0.1 mg/kg bw). There was no relationship between either the AUC for acylamide or acylamide hemoglobin adducts and liver glycidamide DNA adducts. There was also a significant linear relationship between steady-state levels of glycidamide hemoglobin adducts and liver glycidamide DNA adducts for repeat dosing with acrylamide (1-2 mg/kg bw/d). These results suggest that glycidamide hemoglobin adduct levels can predict glycidamide DNA adduct levels when DNA samples are not available. |
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Poster Presentations and Awards
6:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Room 104, Poster
Sci-Mix
Division of Chemical Toxicology |