Magnetic silica nanotubes for drug delivery: Synthesis, characterization and in vitro evaluation

POLY 231

Anjan Nan, anan@rx.umaryland.edu1, Xia Bai, xbai@umd.edu2, Sang Jun Son, triaza@gmail.com2, Sang Bok Lee, slee@umd.edu3, and Hamid Ghandehari, hghandeh@rx.umaryland.edu4. (1) Pharmaceutical Sciences, Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, 20 Penn Street, Room 622 (HSFII), Baltimore, MD 21201, (2) Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, (3) Department of Chemistry and Biochemistry, University of Maryland, 0107 Chemistry Building, University of Maryland, College Park, MD 20742, (4) Department of Pharmaceutical Sciences, Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, School of Pharmacy, 20 Penn Street-Room 625, Baltimore, MD 21201-1180
Recent advances in nanotechnology have made possible the fabrication of magnetic silica nanotubes (MNTs) (silica-iron oxide composites) of monodisperse structures with potential in image guided drug delivery. Limited information is available about the interaction of these nanotubes with the biological environment. Current work evaluates the influence of size and surface properties of MNTs on cytotoxicity and cellular uptake by normal and cancer cells. MNTs were prepared by template synthesis and selectively functionalized to contain positive charge on the outer surface. Cytotoxicity was assessed on model endothelial and breast cancer cell lines. Cellular uptake of fluorescently labeled MNTs was monitored by confocal microscopy. MNTs resulted in limited toxicity which can be controlled as a function of size, concentration and surface charge. Confocal studies provided visual evidence that MNTs are internalized by cells demonstrating their potential for targeted drug delivery.
 

7th International Biorelated Polymers Symposium
8:30 AM-12:40 PM, Monday, 11 September 2006 San Francisco Marriott -- Salon 14/15, Oral

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006