ANYL 101 |
| Fluorescent detection in near-infrared (near-IR) is widely used in variety of bioanalytical applications. The technique has been demonstrated to provide overall better detection efficiencies compared to the UV and visible regions. However there is a major limitation associated with its full utilization. This is the limited set of fluorophores that possess favorable chemical and photochemical properties. The demands of the modern multiplexing analysis require the development of new near-IR fluoropohores with a diverse range of photophysical properties and functional groups for labeling of different targets. Here, we will present newly developed water-tolerant phthalocyanine dyes that possess UV absorbance and fluorescence in near-IR range. The dyes were successfully covalently attached to oligonucleotide probes and the conjugation conditions were optimized. The conjugates were characterized and their bioanalytical applications will be reported.
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General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |