Synthesis of biodegradable poly(urethane urea) by gas phase addition of water

POLY 608

J. O. Basse Asplund, basse@polymer.uu.se1, Tim Bowden1, Torbjörn Mathisen, torbjorn.mathisen@radi.se2, and Jöns Hilborn, joens.hilborn@polymer.uu.se1. (1) Department of materials chemistry, Uppsala University, Lägerhyddsvägen 1, Uppsala, 752 21, Sweden, (2) Radi Medical Systems, Palmbladsgatan 10, Uppsala, Sweden
A new and simple one-pot method to synthesise poly(urethane urea)s with hard segments derived only from diisocyanate has been developed. The hard segment is linked via urea linkages facilitating strong hydrogen bonding. Through slow and continues addition of water in vapour phase, creation of amine in situ followed by urea formation was possible. This synthesis method eliminates the tedious control to approach stoichiometry, is less sensitive to impurities, involves no intermediate isolation steps and do not involve any chain extender. A study using a two armed poly(e-caprolactone) as soft segment and methyl 2,6-diisocyantohexanoate (LDI) as the hard segment was performed. The length of the hard segment was varied from 4.8 to 11.6 LDI-units. Stress strain measurements showed an increase in elastic modulus, 146 to 235MPa, when increasing the hard segment length, while the elongation at break decreased, 980-548%.
 

7th International Biorelated Polymers Symposium
1:30 PM-5:20 PM, Wednesday, 13 September 2006 San Francisco Marriott -- Salon 14/15, Oral

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006