Enzyme positional assembly in polymeric capsules

POLY 390

Jan C. M. van Hest, j.vanhest@science.ru.nl1, Dennis M. Vriezema, vriezema@sci.kun.nl1, Paula ML. Garcia1, Alan E. Rowan, A.Rowan@science.ru.nl2, Roeland J. M. Nolte, R.Nolte@science.ru.nl2, and Jeroen J. L. M. Cornelissen, j.cornelissen@science.ru.nl2. (1) Department of Organic Chemistry, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands, (2) Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands
Nature is capable of performing multistep cascade reactions in a very efficient manner. The level of control Nature can achieve is unsurpassed when compared to our own synthetic abilities. In order to obtain this high level of efficiency, the enzymes involved in a metabolic pathway are non-covalently organized in clusters, with as a result that the product of one catalytic step can be directly used as substrate for the next. In the line of research presented in this paper we want to mimic these so-called metabolons by compartmentalizing and positionally assembling multiple enzymes in a well-defined nanoreactor, a polymeric vescicle or polymersome.

Biocatalysis in Polymer Science
1:30 PM-4:45 PM, Tuesday, 12 September 2006 San Francisco Marriott -- Salon 12/13, Oral

Division of Polymer Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006