Synthesis and characterization of water-dispersible lycoxanthin derivatives

AGFD 66

Henry L. Jackson, hjackson@hibiotech.com, Prostatix Chemistry, Cardax Pharmaceuticals, 99-193 Aiea Hts Dr, ste 400, Aiea, HI 96701, Cristi Braun, Chemistry, Cardax Pharmaceuticals, 99-193 Aiea Hts Dr, ste 400, Aiea, HI 96701, and Samuel F. Lockwood, Chief Scientific Officer, Cardax Pharmaceuticals, 99-193 Aiea Hts Dr, ste 400, Aiea, HI 96701.
Epidemiological studies support an association between consumption of carotenoid-rich foods and decreased risk of diseases such as various cancers and cardiovascular diseases. Most carotenoids lack appreciable solubility in water, limiting the exploration of their therapeutic potential. Previously, we have shown that the aqueous dispersibility of the xanthophyll carotenoids astaxanthin and lutein can be increased through derivatization. In the current study the total synthesis and characterization of the rare C40 lycopene xanthophyll lycoxanthin will be described. The preparation and characterization of a number of derivatives which exhibit increased water dispersibility over the parent lycoxanthin will also be discussed.

 

General Posters
1:00 PM-3:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Agricultural & Food Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006