ANYL 225 |
| The mobility of an ion through a buffer gas, under the influence of a uniform field depends upon the ion's shape and charge, as well as details associated with the ion neutral collisions. This talk focuses on two aspects of mobility measurements: 1) the use as a structural probe of proteins, peptides and amino acid clusters; and 2) the inclusion of an additional mobility dimension for analysis of complex mixtures of proteins encountered in proteomics. Several examples will be presented, including: 1) changes in protein ion structure that appear to occur as ions are stored in paul trap; 2) the role of chirality in assembling amino acid clusters; and, 3) the application of these technologies to the human plasma proteome and the aging proteome of a model organism (Drosophila melanogaster, the fruit fly). Finally, directions for future development of these techniques will be discussed. |
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Bioanalytical Applications of Ion Mobility Mass Spectrometry, Supported by Waters Corporation
8:30 AM-12:05 PM, Tuesday, 12 September 2006 Moscone Center -- Room 124, Oral
Division of Analytical Chemistry |