Using glycodendrimers to study protein-carbohydrate interactions

ORGN 342

Mary J. Cloninger, mcloninger@chemistry.montana.edu, Mark L. Wolfenden, mwolfenden2000@yahoo.com, Eric K. Woller, ewoller@chemistry.montana.edu, and Joel R. Morgan. Department of Chemistry and Biochemistry and Center for Bioinspired Nanomaterials, Montana State University, Bozeman, MT 59717
Protein-carbohydrate interactions on the cell surface play key roles in many cellular processes including the infection of host cells by viruses and bacteria and the adhesion and metastasis of cancer. Assays with glycodendrimers bearing mixtures of low and high affinity carbohydrates presented in a variety of patterns suggest that the degree of lectin clustering and the affinity of the dendrimers for the lectins can be predictably attenuated.