QM/MM methods for large scale biochemical simulations: Implementation in NWChem computational chemistry package

COMP 56

Marat Valiev, marat.valiev@pnl.gov, Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, MS K8-91, Richland, WA 99352
This presentation will be focused on the recently implemented QM/MM module in NWChem, freely available computational chemistry package designed to run on high-performance parallel supercomputers as well as conventional workstation clusters. Taking advantage of the modular structure of the code, the NWChem QM/MM implementation offers an integrated and flexible framework for large scale biochemical simulations (single point properties, optimizations, dynamics, free energy). An example application to photostability of DNA will also be discussed.