POLY 416 |
| Polymeric nanogel carriers significantly enhanced stability and biological activity of encapsulated nucleotide and oligonucleotides. Chemical engineering of nanogel structure could increase bioavailability and decrease cytotoxicity of nanogels. Pluronic®-based nanogels were obtained with good yields and small particle size using a novel micellar synthesis. Preparation of nanogels from a biodegradable PEI resulted in significantly less toxic carriers. Nanogel network contained disulfide bonds readily degraded following treatment with reducing agent. Degradation products expected to have a lower toxicity and better clearance than nanogels. Cellular accumulation of nanogels increased in the following order PEG |
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7th International Biorelated Polymers Symposium
6:00 PM-8:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Division of Polymer Chemistry |