ANYL 312 |
| Modern SFC instrumentation has developed to the point where SFC is now as facile as is LC. Fully automated SFC instruments can now pump from 1 g/min to 350 g/min, allowing the chromatographer the ability to start with an analytical SFC method and continue to kilo scale separations. Given the enormous advantages of SFC over LC (methods development time, solvent consumption, safety, resolution, inter alia), all analytical chromatographers should consider switching to SFC, especially for samples that may eventually require collection at even the milligram scale. SFC is now commonly used for chiral stationary phase separations since these resolutions are largely normal phase separations. SFC combined with mass spectrometric detection is a tool that offers “on the fly” identification of analytes at high sensitivity. This extends the utility of SFC into separations on achiral stationary phases. The reduced run times of a separation by SFC compared to the same separation by LC makes SFC an attractive alternative for repetitive or routine analyses. An analytical operation using SFC instead of LC can increase its sample throughput of by a factor of two to five and greatly reduce consumption of expensive resources. The author will present details of his work on analytes related to the pharmaceutical and neutraceutical sciences. |
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Analytical Approaches: Separation Science
8:30 AM-12:00 PM, Thursday, 14 September 2006 Moscone Center -- Room 130, Oral
Division of Analytical Chemistry |