POLY 490 |
| A study of entrapment of gold nanoparticles in biodegradable micelles as potential labeling technique for cellular internalization is presented. Poly(ethylene oxide)-b-Poly(ε-caprolactone) (PEO-b-PCL) copolymer terminated with thioactic ester functionality at the end of the PCL block was prepared, and used to form the monolayer protected gold nanoparticles via the disulfide moiety. At relatively high copolymer grafting densities, stable dispersions were obtained upon dissolution in many selective solvents, commonly used in dissolving the free copolymer. The average diameter of the gold nanoparticles was 6-8 nm as determined by transmission electron microscopy (TEM). At lower grafting densities, on the other hand, large gold cluster of 50-100 nm to insoluble materials were the main products. Micelles prepared in aqueous solutions showed core-shell structures of 5-7 nm in gold core and ca. 7 nm of polymeric shell. The study summarizes the synthesis, characterization and aggregation behavior of gold-capped PEO-b-PCL block copolymer micelles, a potential system in drug delivery.
|
|
Nanoparticles and Microparticles: Synthesis and Applications
6:00 PM-8:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Polymer Chemistry |