Although the pharmacophoric peroxide bond in artemisinin and synthetic peroxides is essential, it is not sufficient for high antimalarial potency.  Therefore, understanding peroxide bond reactivity is important in elucidating the mechanistic chemistry that underlies the antimalarial action of peroxide antimalarials.  Building on the discovery and mechanistic studies of antimalarial 1,2,4-trioxolane 1 and 1,2,4-trioxane 2, we synthesized and evaluated the structurally related 1,2-dioxolane 3, the isoelectronic analogue of 1.  Dioxolane 3 is expected to have increased O-O bond stability that precludes the Hock fragmentation characteristic of trioxolanes and trioxanes. The synthesis, chemical stability, and antimalarial activity of 1,2-dioxolanes will be discussed.