I&EC 153 |
| Cyclopropylamine is becoming an increasingly important moiety in pharmaceutical formulations used as anti-viral agents and antibiotics for the treatment of drug resistant bacterial strains. As a consequence, market demand has become large enough to a continuous process. Eastman Chemical Company has developed a continuous process using a plug flow reactor to convert of cyclopropyl amide to cyclopropyl amine via the Hofmann rearrangement utilizing sodium hypochlorite and caustic. Critical to developing this process was the application of in situ infrared and UV-visible spectroscopy where these spectroscopic methods were used (1) to develop an understanding of competing pathways, (2) to measure kinetic parameters for the sequential rearrangement steps which ultimately determined the reactor design, (3) to monitor reactor performance during development, and (4) to develop a control strategy for the continuous process. We will discuss the role of these spectroscopic methods in the development of the continuous cyclopropylamine process. |
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In Situ Spectroscopic Monitoring in Process Development and Production, Sponsored by Novel Chemistry with Industrial Applications Sub-Division
8:30 AM-12:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 252/254, Oral
Division of Industrial & Engineering Chemistry |