Drug loading in Rf-PEG (fluoroalkylended poly(ethylene)glycol) hydrogels as studied by NMR spectroscopy

ANYL 54

Errol V. Mathias, emathia@exchange.calstatela.edu1, Xiangli Liu, lucy2468@sbcglobal.net1, Anuja Prabhutendolkar1, Yong Ba, yba@calstatela.edu1, and Julia A. Kornfield, jak@cheme.caltech.edu2. (1) Department of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, (2) Division of Chemistry and Chemical Engineering, California Institute of Technology, Mail Code 210-41, Pasadena, CA 91125
The Rf-PEG (fluoroalkyl-ended Poly (ethylene) glycol) hydrogels are very good candidates for delivering hydrophobic drugs. A spin labeled analogue of chlorambucil, an anticancer drug was loaded into these hydrogels. Liquid and solid-state NMR T1 (spin lattice) relaxation times were studied to analyze the impact of the spin label, tempol on the methylene chains of PEG and the fluoroalkyl chains of the Rf groups. The 1H T1 relaxation times of the PEG and the 19F T1 relaxation times of the Rf groups were found to be dependent on the concentration of loaded drug. The maximum amount of drug loading could thus be calibrated from the T1 relaxation times.
 

General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Analytical Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006