CHED 270 |
| Chelation chemistry can serve as the foundation for therapies to ameliorate aberrant metal accumulations. The interaction of porphyrins with radioisotopes commonly used in nuclear medicine imaging was investigated using electronic and vibrational spectroscopes. Cationic and anionic porphyrins were selected to study the influence of the porphyrin charge on their ability to chelate the metal ions. Complexes of Ga (III), Gd (III), In (III) and Tl (III) with porphyrins in aqueous solution at different pH values and metal ion concentrations were investigated. The fluorescence, infrared, Raman and UV visible spectra indicate a strong interaction between the metal ions and porphyrins. A correlation between the vibrational modes of the complexes and the ionic radius of the metal ion has been found. The ability of the porphyrins to bind metal ions depends on the basicity of the porphyrin and the nature of the charge of the porphyrin side chain.
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Undergraduate Research Poster Session: Inorganic Chemistry
2:30 PM-4:30 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster
Division of Chemical Education |