CHED 234 |
| The impressive biological activity of dihydropyrimidines accounts for the strong current interest in the Biginelli reaction, a one-pot reaction involving urea, an acetoacetic ester and an aryl aldehyde. We have developed a robust, microwave-assisted, microscale version of the Biginelli reaction in which copper(II)aspirinate is used to promote the reaction. This method yields material suitable for spectroscopic analysis well within the constraints of a three-hour laboratory and offers many alternatives for an inquiry-based laboratory experience.
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Undergraduate Research Poster Session: Chemical Education
2:30 PM-4:30 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster
Division of Chemical Education |