Functionalized diaziridines as potential electrophilic aziridinating agents

CHED 304

Ryan J. Yoder, rjyoder@owu.edu and Katherine L. Hervert. Department of Chemistry, Ohio Wesleyan University, 61 S. Sandusky Street, Delaware, OH 43015
Aziridines are present in several antitumor and antibiotic natural products, such as the mitomycin, porfiromycin, and the FR and FK compounds. We plan to pursue a simple N-H aziridination method, which is a relatively limited area of synthetic organic chemistry. Diaziridines, the nitrogen equivalent of dioxiranes, represent a promising class of aziridinating agents for alkenes. Modeling the electrophilic dioxirane epoxidation methods, we hope to develop an efficient aziridinating agent using functionalized diaziridines.