Use of flow-through dissolution cell for the in vitro study of bioavailability of drugs

CHED 203

Cristina De Melo1, Marc M. Baum, m.baum@oak-crest.org1, and Thomas J. Smith2. (1) Department of Chemistry, Oak Crest Institute of Science, 2275 E. Foothill Blvd., Pasadena, CA 91107, (2) Auritec Pharmaceuticals, 2275 E. Foothill Blvd., Pasadena, CA 91107
An increasing number of drugs both in the market and under development are very poorly soluble in water. Dissolution tests for these drugs are challenging and traditional in vitro dissolution systems may not be suitable for the study of these compounds. A novel flow-though system is presented for the study of dissolution of poorly water soluble drugs. Data from the low solubility corticosteroid rimexolone will be presented as an example of the usefulness of the system.
 

Undergraduate Research Poster Session: Biochemistry
2:30 PM-4:30 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster

Division of Chemical Education

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006