CHED 222 |
| Penicillin-binding proteins (PBPs) catalyze the synthesis of peptidoglycan, the structural component found in bacterial cell walls. They are targeted by β-lactam antibiotics and as a result, constitute an important area of study, especially with regards to multi-drug resistance. Each type of β-lactam binds preferentially to one or more types of PBPs, giving rise to a characteristic inhibition pattern. Identifying the characteristic inhibition patterns of well studied E. coli PBPs by a set of β-lactams would be useful in identifying the same types of PBPs in other bacterial species on the basis of inhibition. Studies comparing PBPs using fluorescently-labelled penicillin derivatives will be described. |
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Undergraduate Research Poster Session: Biochemistry
2:30 PM-4:30 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster
Division of Chemical Education |