CHED 294 |
| In order to expand the scope of natural proteins, the synthesis of suitably protected designer amino acids incorporating N-heterocyclic carbenes (NHC's) is presented. These new amino acids are based on a phenylalanine framework which is modified by metal-catalyzed coupling chemistries or aromatic substitution reactions. The design of a NHC-containing amino acid is expected to expand the scope of unnatural amino acid suppression, leading to the incorporation of a very reactive sidechain for covalent modification of natural proteins. In addition, the high binding constants of NHC's for metal ions will allow the synthesis of metal-bound peptides for pharmaceutical purposes. |
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Undergraduate Research Poster Session: Organic Chemistry
2:30 PM-4:30 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster
Division of Chemical Education |