INOR 329 |
| The work described is a ligand-structure-focused approach to improving both activity and selectivity in Ni-catalyzed multi-component reactions. The initial approach to experiments is guided by phenomena characterized in the recent literature: N-heterocyclic carbenes (NHCs) promote greater activity and tolerate a broader variety of conditions and substrates than phosphine ligands in similar reactions. Initial screenings utilize chiral NHCs that may be chiral in the N-alkyl side chain, the saturated backbone or, in cases, have a planar chiral element. The effect of rigidity of the N-side chain, heterocycle size, and nickel source will also be explored. The scope of the project include 1) selection of a primary set of ligand candidates; 2) determination of asymmetric induction levels in reactions promoted by achiral NHCs or phosphines, utilizing initial candidates and variants as needed; 3) comparison of stereoselection in reactions with non-racemic chiral substrates. |
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Organometallic: Catalysis
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Inorganic Chemistry |