CHED 327 |
| Inhibition of inosine monophosphate dehydrogenase (IMPDH) can play an important role in antileukemic and immunosuppressive therapies. By protein crystallography, it is known that this enzyme binds 5'-IMP as its lower energy anti glycosidic rotamer. To date, the first 8 steps along an 11-step synthetic route towards an 8,5'-transglycosidically tethered version of 5'-IMP locked in an anti conformation have been accomplished, giving an 8,5'-methyleneoxo tethered version of inosine as a cyclic hemiacetal. Details of the multi-step nucleoside synthesis and progress toward the final tethered IMP target will be presented. Ultimately, the target 5'-IMP analog diastereomers will be tested separately in an IMPDH enzyme assay with the goal of highlighting a new platform for constructing even more effective antileukemic chemotherapeutics. |
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Undergraduate Research Poster Session: Organic Chemistry
2:30 PM-4:30 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster
Division of Chemical Education |