INOR 1036 |
| Mononucleating pyridyl-amine ligands with water-soluble sulfonate, carboxylate, or hydroxyl pendent groups of varying tether lengths and numbers of N-atom donors have been designed and synthesized along with their corresponding Zn(II), Cu(II), Co(II), and Ni(II) metallohydrolase model complexes. The effects of the length and the rigidity of the water-soluble pendent on the structures of the metal complexes will be discussed, along with studies on the reactivities of these model compounds towards promoting the hydrolysis of activated carboxy and phosphate esters and DNA. The structural-reactivity correlations in the reactivity of the metallohydrolase model complexes will also be presented along with correlations between the number of N-atom donors and reactivity. In addition to the mononucleating ligands, heterodinucleating ligands and complexes have also been prepared to model dinuclear metallohydrolases. These ligands and complexes will also be discussed. |
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General
1:30 PM-4:10 PM, Thursday, 14 September 2006 Moscone Center -- Room 304, Oral
Division of Inorganic Chemistry |