INOR 147 |
| Inorganic chemistry and biology have great potential for cross-fertilization. Although major progress has been made in using synthetic and physical inorganic chemistry to understand metal ions in biological systems, the time may be right to take advantage of biological machinery to advance inorganic coordination chemistry. A natural extension of biomimetic studies of native metalloenzymes is the use of small, stable, easy-to-produce and well-characterized proteins as “ligands” to synthesize novel inorganic compounds that will allow new and deeper insight into the principles of coordination chemistry. This approach, thus called biosynthetic inorganic chemistry, is feasible because of current advances in molecular biology, biochemistry and biophysics. These biosynthetic complexes can be used to create either, close biomimetic models of complex native enzymes, or metalloproteins with structures and reactivities unprecedented in nature. Recent progress in this field, including syntheses and studies of a heteronuclear heme-CuB center (Figure A), an asymmetric Mn(Salen) catalyst in protein (Figure B) and a mixed-valence dinuclear CuA center (Figure C), will be presented.
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Bioinorganic Chemistry
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Inorganic Chemistry |
