INOR 936 |
| The zinc-containing enzyme ALAD catalyzes the second stage of porphyrin synthesis. Substitution of Zn by Pb causes the pathway to shut down, leading to anemia and neurological damage from excess 5-aminolevulinic acid. We discuss computational models of several competing mechanisms for the activity of the native form of ALAD, and the effect of lead substitution upon them. |
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Bioinorganic Modeling
1:30 PM-5:30 PM, Wednesday, 13 September 2006 Moscone Center -- Room 307, Oral
Division of Inorganic Chemistry |