Investigation of single-walled carbon nanotubes for near-infrared fluorescence detection of DNA sequences

INOR 113

Esther S Jeng, ejeng@uiuc.edu, Department of Chemical and Biomolecular Engineering / Strano Research Group, University of Illinois Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL 61801 and Michael S. Strano, strano@uiuc.edu, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801.
Single-walled carbon nanotubes (SWNT) have the potential to be utilized in materials for a variety of sensors. When individually dispersed, semiconducting SWNT exhibit band-gap photoluminescence at near-infrared (nIR) wavelengths. The nIR region is critical in many biological detection schemes, as interference from cell autofluorescence and light absorption of whole blood and tissue is low at these wavelengths. In previous work we report the synthesis of oligonucleotide-SWNT materials for detection of a specific DNA sequence. The oligo-SWNT allow for label-free nanoscale detection through a modulation in the nIR fluorescence energy caused by hybridization of complementary oligo strands on the nanotube surface. We report here in further studies an evaluation of this nanoscale sensor with respect to its size, geometry and kinetic properties.
 

Nanoscience: Applications
1:30 PM-4:30 PM, Sunday, 10 September 2006 Moscone Center -- Room 309, Oral

Division of Inorganic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006