INOR 173 |
| Pyridyl-amine ligands containing water-soluble sulfonate groups with varying tether lengths have been synthesized along with their corresponding Cu(II), Ni(II), and Zn(II) complexes, and several of the complexes have been structurally characterized by X-ray crystallography. To test the abilities of these new complexes towards promoting the hydrolysis phosphoester bonds, each was reacted with bis(4-nitrophenyl)phosphate in buffered water under various pseudo first-order conditions. The complexes were also reacted with Litmus 29 plasmid DNA under both anaerobic and aerobic conditions to test for phosphodiester cleavage of the DNA backbone by comparing the relative amounts of resulting supercoiled, nicked, and linear DNA. The data produced offer interesting insights on the effect of the sulfonate tether length in modulating the reactivities of the complexes.
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Coordination Chemistry: Synthesis
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Inorganic Chemistry |
