CHED 285 |
| Malignant melanoma is responsible for 75%-90% of all skin cancer related deaths. The development of antibodies for the detection of specific melanoma biomarkers would greatly increase the ease and speed of detection and could lead to methods for routine monitoring of patients following surgical treatment. 5-S-cysteinylydopa (5-SCD) has been shown to be the best diagnostic marker of malignant melanoma; however its oxidative instability makes it difficult to test in plasma or urine. An immunoassay for 5-SCD would provide an effective and economical method for the detection of malignant melanoma in skin cancer patients. Previous attempts to identify an antibody for 5-SCD have demonstrated limited selectivity. We plan to identify antibodies with high affinity and specificity using antibody phage display libraries. We are synthesizing a 5-SCD analog containing a biotin moiety for phage display screening. Preliminary results will be presented on the synthesis of 5-SCD. Initial synthesis and characterization of 5-SCD containing biotin will also be presented. |
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Undergraduate Research Poster Session: Organic Chemistry
2:30 PM-4:30 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Poster
Division of Chemical Education |