Dynamic combinatorial libraries of histidine-based oligomers

INOR 181

Masa Matsumoto, Masaomi.matsumoto-1@ou.edu, Department of Chemistry, University of Oklahoma, 620 Parrington Oval, Norman, OK 73069 and Kenneth M. Nicholas, KNicholas@ou.edu, Department of Chemistry and Biochemistry, University of Oklahoma, 620 Prrington Oval, Norman, OK 73019.
Dynamic combinatorial chemistry can give access to structures that would be difficult or impossible to synthesize by traditional means. Acid-catalyzed hydrazone-exchange has been demonstrated to be a suitable reversible reaction for Dynamic Combinatorial Libraries (DCL). The synthesis of functional models of metalloenzyme active sites is of great interest. To this end, we have produced dynamic libraries of histidine-based oligomers. Recent progress in characterization of libraries and templating behavior will be reported.

 

Coordination Chemistry: Synthesis
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Inorganic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006