In situ formation of tridentate ligands in aqueous media from 2, 4-pentanedione to form imine complexes around [M(CO)3(OH2)3]+ (M=Re, 99mTc) centers

INOR 184

Glenn A. Fugate, gfugate@wsu.edu, Brienne N. Bottenus, and Paul Benny, bennyp@wsu.edu. Department of Chemistry, Washington State University, PO Box 644630, Pullman, WA 99164-4630
Exploration of new methods for radiolabeling that enhance biological affinity and separation has led this investigation to prepare a multidentate compounds by reacting 2 ligands on a metal center. A family of 2, 4-pentanedione (acac) complexes with the [M(CO)3(OH2)3]+ (M=Re, 99mTc) species has been synthesized on the macroscopic and radiotracer level. Several “2 + 1” type donor systems complexes of the form [M(CO)3(acac)L] were made where M = Re or Tc-99m and L is a simple amine ligand such as pyridine. Tridentate ligands were synthesized using the metal center as a template. The reaction of acac with a compound containing two amine groups such as 2-(2-aminoethyl)pyridine forms a tridentate ligand via the formation of an imine. These two step, one pot type of reactions may be a useful means of attaching chemical sensitive target seeking compounds to radioisotopes centers of interest.
 

Coordination Chemistry: Synthesis
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Inorganic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006