Hydroxypyridonate-based Gd(III)-chelates incorporated into ring-opening metathesis polymerization-derived polymers as sensitive imaging agents

INOR 695

Matthew J. Allen, mallen@biochem.wisc.edu, Departments of Biochemistry and Chemistry, University of Wisconsin--Madison, 1101 University Avenue, Madison, WI 53706, Ronald T. Raines, raines@biochem.wisc.edu, Departments of Biochemistry and Chemistry, University of Wisconsin - Madison, Madison, WI 53706, and Laura L. Kiessling, kiessling@chem.wisc.edu, Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706.
A monomer for ring-opening metathesis polymerization (ROMP) has been developed that contains a hydroxypyridonate-based Gd(III)-chelating moiety. The multivalent imaging agents were generated by polymerization and introduction of the metal. When these were evaluated, an increase in per Gd(III) relaxivity was detected upon transition from monomer to polymer. Extremely large molecular relaxivities were achieved through incorporation of multiple Gd(III) ions per polymer. High relaxivity values indicate the potential utility of these oligomers as contrast agents for magnetic resonance imaging. Finally, the nature of ROMP-derived polymers allows for functionalization of the monomer units and termini through orthogonal chemistry. Our strategy is the basis for a new class of highly sensitive, targeted imaging agents.

 

General
7:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Inorganic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006