Synthesis and luminescence and cytotoxicity studies of rhenium(I) 8-hydroxyquinolinato and 8-mercaptoquinolinato complexes

INOR 146

Dejene K. Orsa, br24wn@yahoo.com1, David M. Kimari, mkimari3@yahoo.com2, Saroj K. Pramanik, sarojpramanik@yahoo.ca3, Arthur L. Williams, awillia5@morgan.edu3, Maurice O. Iwunze, miwunze@jewel.morgan.edu1, George E. Greco, ggreco@goucher.edu4, Douglas M. Ho, ho@princeton.edu5, Jeanette A. Krause, Jeanette.Krause@uc.edu6, and Santosh K. Mandal, smandal@morgan.edu1. (1) Department of Chemistry, Morgan State University, 1700 E. Cold Spring Lane, Baltimore, MD 21251, (2) Department of Bio-Environmental Science, Morgan State University, 1700 E. Cold-Spring Lane, Baltimore, MD 21251, (3) Department of Biology, Morgan State University, 1700 E. Cold Spring Lane, Baltimore, MD 21251, (4) Department of Chemistry, Goucher College, 1021 Dulaney Valley Road, Baltimore, MD 21204, (5) Department of Chemistry, Princeton University, Princeton, NJ 08544-1009, (6) Department of Chemistry, University of Cincinnati, P. O. Box 21072, Cincinnati, OH 45221-0172
The reactions of the molecular rectangle, Re4 (CO)12(m-OC5 H11)4(m-4,4'-bipy)2, with 8-hydroxyquinoline and 8-mercaptoquinoline, in 1:4 mole ratio, yielded the dirhenium 8-hydroxyquinolinato and 8-mercaptoquinolinato complexes, Re2 (CO)6(m-4,4'-bipy)(XQ)2, (X=O or S), respectively, in almost quantitative yields. The complexes were characterized spectroscopically and the 8-hydroxyquinolinato complex was characterized through X-ray crystal structure determination. Both complexes are luminescent and cytotoxic against breast cancer and prostate cancer cell lines. A detailed studies on the luminescence properties and cytotoxicities of the two complexes will be presented.
 

Bioinorganic Chemistry
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Inorganic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006