Titania metal oxide microspheres and nanoparticles from Ultrasonic spray pyrolysis: Preparation, endocytosis, and cytotoxicity

INOR 302

Won Hyuk Suh, wonsuh@uiuc.edu1, Ah Ram Jang, ibar0904@gmail.com2, Yoo-Hun Suh, yhsuh@snu.ac.kr2, and Kenneth S. Suslick, ksuslick@uiuc.edu1. (1) School of Chemical Sciences, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL 61801, (2) Department of Phamacology, College of Medicine, Seoul National University, National Creative Research Initiative for Alzheimer's Dementia and Neuroscience Research Institute, MRC, 28 Yeongeon-dong, Jongno-gu, Seoul, 110-799, South Korea
Porous, hollow, and ball-in-ball metal oxide (titania) microspheres were synthesized using an inexpensive ultrasonic generator (household humidifier; ultrasonic spray pyrolysis). Morphology and pore size were controlled by the silica to Ti(IV) ratio and silica particle size. Depending on these factors sub-50 nm oxide nanoparticles can be synthesized as well. With the introduction of transition metal ions, core-shell type microspheres can be synthesized in a single-pot synthesis. These nanomaterials are rapidly taken up into the cytoplasm (but not the nucleus) of mammalian cells and show very little cell toxicity (cytotoxicity). Small molecules like Rhodamine and DHED (dehydroevodiamine HCl; Alzheimer's disease therapeutic) can be delivered along with them. Characterization methods used were SEM, (S)TEM, optical/confocal microscopy, XRD, EDS, SAED, zeta potential, and BET.

 

Nanoscience: Applications
7:00 PM-10:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Inorganic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006