NUCL 107 |
| Engineering the permanent formation of a receptor-ligand complex has a number of potential applications in chemistry and biology, including targeted medical imaging and therapy. These systems can be prepared by a combination of protein engineering and synthetic chemistry, for example using the incorporation of chemically reactive groups at the periphery of an antibody's binding surface, paired with the chemical design of complementary reactive ligands, to produce receptor-ligand pairs that associate efficiently and permanently under physiological conditions. An exemplary system involving metal-DOTA complexes shows that this approach can lead to the straightforward production of infinite binding ligand-protein pairs beginning from weakly binding starting materials. We will describe recent advances and the first in vivo results. Supported by NIH research grants CA016861 and CA098207, and NIH Shared Instrumentation Grant RR014701. |
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Recent Advances in Molecular Imaging
1:25 PM-4:50 PM, Thursday, 14 September 2006 Moscone Center -- Room 270, Oral
Division of Nuclear Chemistry & Technology |