Novel apple seed beta-glucosidases useful for alkyl glycosides synthesis

CARB 73

Jian-He Xu, jianhexu@ecust.edu.cn and Hui-Lei Yu. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China
Apple seed was identified as a new promising beta-glucosidase source for alkyl O-glucoside synthesis by reverse hydrolysis, since it showed high hydrolytic activities on a broad spectrum of beta-glucosides. From the crude extract of apple seed meal, a major glucosidase isoenzyme was purified to homogeneity, with a purification factor of 47-fold and an overall yield of 12.8%. The purified enzyme is a homodimer; each subunit has a molecular mass of about 60 kDa and the pI of this beta-glucosidase is about 5.7. Furthermore, the purified enzyme of apple seed displays higher thermal stability than the commercially supplied beta-glucosidase from almond, with half-lives of 42.9 h and 14.2 h respectively as preserved at 50 oC in an aqueous environment. The optimum pH of the apple seed beta-glucosidase was 6.0 and the stable pH range was 5.0-9.0, both similar to those of the commercial almond beta-glucosidase.
 

General Posters
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster

Division of Carbohydrate Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006