Biocompatible hydrogel-coated gold nanoparticles for in vivo drug delivery

COLL 102

T. Randall Lee, trlee@uh.edu, Departments of Chemistry and Chemical Engineering, University of Houston, 4800 Calhoun Road, Houston, TX 77204-5003 and Jun-Hyun Kim, jun-kim@northwestern.edu, Department of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208-3113.
Co-polymerization of a mixture of N-isoproprylacrylamide and acrylic acid in the presence of surface-modified gold nanoparticles leads to the preparation of biocompatible hydrogel-coated composite nanoparticles. Controlled collapse of the hydrogel coating can be thermally or photolytically induced by heating slightly above physiologic temperature. These new composite nanoparticles offer unique opportunities as discrete biocompatible drug-delivery vehicles.
 

Advances in Nanomedicine
2:00 PM-5:30 PM, Sunday, 10 September 2006 Sir Francis Drake -- Monterey/Cypress Rooms, Oral

Division of Colloid & Surface Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006