Synthesis and characterization of some Schiff Base complexes of vanadium(V)–A search for an effective insulin-enhancing compound

INOR 75

Alvin A. Holder, aaholder@yahoo.com1, Gabriel R. Harewood, gabriel.harewood@uwimona.edu.jm2, Kerry-Ann Green, kerrann.green@uwimona.edu.jm2, Paul T. Maragh, paul.maragh@uwimona.edu.jm2, and Tara P. Dasgupta, tara.dasgupta@uwimona.edu.jm2. (1) Department of Chemistry and Biochemistry, The University of Southern Mississippi, Hattiesburg, MS 39406, (2) Department of Chemistry, University of the West Indies, Mona, Kingston 7, Jamaica
Several new vanadium(V) complexes with Schiff Bases as ligands were synthesized. Schiff Bases were generated in solid state by condensation of salicylaldehyde or azo derived salicylaldehyde with tris(hydroxymethyl)aminomethane and characterized. The vanadium(V) complexes were synthesized by reacting with stoichiometric amounts of either VO(acac)2 (where acac = acetylacetonate) or VOSO4. In the case of VOSO4, water was used as the solvent, whereas for VO(acac)2, methanol was the solvent medium. The vanadium(V) complexes were characterized by UV-visible, IR, NMR, and X-ray diffraction. Electrochemical studies were carried out on the complexes in DMSO solution so as to determine the redox potentials of the vanadium center and the effect of ligand environment on the redox potential of vanadium(V). Effectiveness of these compounds in lowering blood glucose in STZ-induced diabetic rats is being investigated.
 

Bioinorganic Chemistry of Vanadium Compounds
2:00 PM-5:40 PM, Sunday, 10 September 2006 Moscone Center -- Room 304, Oral

Division of Inorganic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006