Synthesis and characterization of magnetic nanotube as drug carrier and MRI contrast agent

ANYL 175

Xia Bai, xbai@umd.edu1, Sang Jun Son, triaza@gmail.com1, Anjan Nan, anan@rx.umaryland.edu2, James Shin, shinj7@hotmail.com3, Hamid Ghandehari, hghandeh@rx.umaryland.edu4, and Sang Bok Lee, slee@umd.edu5. (1) Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, (2) Pharmaceutical Sciences, Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, 20 Penn Street, Room 622 (HSFII), Baltimore, MD 21201, (3) University of Maryland College Park, College Park, MD 20706, (4) Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 N. Pine Street, Baltimore, MD 21201-1180, (5) Department of Chemistry and Biochemistry, University of Maryland, 0107 Chemistry Building, University of Maryland, College Park, MD 20742
This work describes the synthesis and characterization of magnetic nanotubes as potential drug carriers for chemotherapy. Current chemotherapy is limited by severe side-effects due to low specificity in cancer cell targeting. Magnetic nanoparticles can be manipulated by an external magnetic filed gradient and can thus be used to deliver anticancer drugs to a targeted region. Additionally, magnetite nanomaterials can be used as MRI contrasting agent. These characters make the MNTs potentially ideal diagnostic / therapeutic systems. The magnetic nanotubes were prepared by template synthesis with aluminum anodic oxide films as templates. The dimensions of the pores in the films can be controlled precisely by anodization potential and time. The magnetic layers were formed by stoichiometric coprecipitation of ferric and ferrous chloride by ammonia water vapor. The template synthesis method makes it possible to modify the inner and outer surfaces of the nanotubes differently. The inner and outer surfaces of the nanotubes were modified before and after the selective dissolution of the template respectively. The properties of the magnetic nanotubes were investigated by transmission electron mircorscopy, electron diffraction spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. T1 and T2* relaxation rates were determined by NMR measurements. The water proton relaxation times were reduced significantly. These preliminary data indicate the potential biomedical applications of the magnetic nanotubes.

 

General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Analytical Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006