ANYL 131 |
| The AMES test is a short-term bacterial reverse mutation genotoxicity assay utilized as an initial screen for determining the mutagenic potential of a new drug candidate. No clear guidelines exist specifying the purity of test compounds for the Ames test at the discovery stage. However, to minimize false positives it is general practice across the industry to ensure the purity of submitted materials is very high (e.g. >99%). Many strategies have been explored to improve efficiency in the method screening and purification of both chiral and achiral compounds. SFC has been found as an efficient and economical tool for purification in drug discovery and facilitates high purity purification of materials. In this poster, several examples are given to show the efficiency and benefits of utilizing SFC to obtain high purity materials for AMES testing. |
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General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |