ORGN 600 |
| We have reported the use of proteases to catalyze the generation of biomimetic macromolecules through the condensation of peptoid fragments. Protease-mediated ligation exploits the inherent proteolytic resistance of peptoids (N-substituted glycine oligomers), coupled with the specificity and catalytic activity of proteases. We now describe the utility of protease-mediated ligation in the synthesis of peptidomimetic oligomers ranging from 11-32 residues, comprised of diverse sequences and side chain functionalities. The ligation reactions can be performed iteratively, enabling the generation of peptoid concatemers – i.e. block segments repeated end-to-end. Our current efforts are directed towards the synthesis of sequence-specific macromolecules comprised of repeating peptoid or hybrid peptoid-peptide segments.
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New Reactions and Methodology, Heterocycles and Aromatics, Bioorganic Chemistry
8:00 PM-10:00 PM, Tuesday, 12 September 2006 Moscone Center -- Hall D, Poster
Sci-Mix
Division of Organic Chemistry |
