TOXI 101 |
| Redox active transition metals modify nucleic acid structure through both binding interactions and oxidation chemistry. This presentation will summarize recent results in the characterization of guanine oxidation products in DNA including one-electron processes leading to either C5 or C8 oxidation products mediated by Ni(II) complexes as well as two-electron oxidation yielding 8-oxo-dG from Pt(IV) compounds. |
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Metal Carcinogenesis: New Concepts
2:00 PM-5:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 308, Oral
Division of Chemical Toxicology |