Studies toward the synthesis of tedanolide

ORGN 733

Joshua R. Dunetz, jdunetz@scripps.edu, Departments of Chemistry and Biochemistry, The Scripps Research Institute, Florida, 5353 Parkside Drive, RE-2, Jupiter, FL 33458, Lisa D. Julian, ljulian@amgen.com, Amgen, Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, and William R. Roush, roush@scripps.edu, Department of Chemistry, Scripps-Florida, 5353 Parkside Drive, RE-2, Jupiter, FL 33458.
Described are studies directed toward the synthesis of tedanolide, a macrolide natural product with promising antitumor activity. Particular attention focuses on the preparation of the C13-C23 fragment and the coupling of this subunit with the C1-C12 fragment via aldol reaction. Also discussed are strategies for the completion of the polyketide target.

 

Total Synthesis, Materials, Molecular Recognition, Process R&D, and Physical Organic Chemistry
8:00 PM-10:00 PM, Wednesday, 13 September 2006 Moscone Center -- Hall D, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, 11 September 2006 Moscone Center -- Hall D, Sci-Mix

Division of Organic Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006