ORGN 617 |
| A variety of diarylacetylenes were obtained in good yields by addition of LiHMDS to a THF solution of arylmethyl sulfone, arylaldehyde and chloro diethylphosphate. In this “one-shot process”, a number of transformations such as aldol reaction, phosphorylation of aldolate, and double elimination of the resulting ?-substituted sulfone proceeded successively to afford the desired acetylenes. This protocol was useful for preparation of diarylacetylenes bearing various functional groups such as halogens, CF3, ethoxycarbonyl, dimethylamino, TMS-acetylene groups as well as pyridinyl and thienyl moieties |
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Modern Acetylene Chemistry
8:15 AM-12:00 PM, Wednesday, 13 September 2006 Moscone Center -- Room 134, Oral
Division of Organic Chemistry |