Ligands for the TRP-M8 receptor found in prostate cancer cells

MEDI 88

Lok Him Yu, ahamindra@berkeley.edu1, Chi Ching Joyce Leung1, Xiaoliu Guo1, and Ahamindra Jain, ahamindra@berkeley.edu2. (1) Chemistry, UC Berkeley, 332 Latimer Hall, Mail Code 1460, Berkeley, CA 94720-1460, (2) Department of Chemistry, University of California, Berkeley, 332 Latimer Hall, Mail Code 1460, Berkeley, CA 94720-1460
Derivatives of menthol that interact with the TRP-M8 receptor have been prepared and evaluated for detection of prostate cancer cells. Bi- and tricyclic analogs have been studied, in the hope of attaining subnanomolar binding affinities. In the longer term, this class of ligand may serve as a delivery agent for lethal radiation to treat prostate cancer in a site-specific manner.
 

General Poster Session
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Medicinal Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006