ORGN 328 |
| This talk will describe the use of small molecules to generate protein-resistive coatings on the surface of Alzheimer's related β-amyloid fibrils. The interaction of aggregated forms of β-amyloid peptides with cellular proteins in the brain have been suggested to play a pathological role in Alzheimer's disease (AD). We will discuss the inhibition of protein-amyloid interactions using synthetic molecules that bind to Alzheimer's related β-amyloid fibrils. We will also present a method to screen for small molecules that bind to β-amyloid fibrils and the potential application of these molecules as lead compounds for the development of therapeutics and diagnostics for AD. |
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Molecular Recognition and Self-Assembly
1:00 PM-5:00 PM, Monday, 11 September 2006 Moscone Center -- Room 132, Oral
Division of Organic Chemistry |